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Besides the IM clusters, we identified an intermediate cell cluster called CMoInt that expressed several CMo and monocyte markers, such as Plac8 , Ccr2 , Ms4a4c and Ly6c2 , illustrating that these cells originated from CMo ( Figures 4A, B , 2C )

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As this epidemic continues to take its toll in the United States, it is also increasing in low- and middle-income countries that are least able to afford the resulting health and economic consequences (Peto and Lopez 2001